Debuffs

Stack Types

• Intensity Debuffs are more effective depending on how many stacks of the debuffs you have. These debuffs typically are either permanent for the combat encounter or are consumed on the following turn.
• Duration Debuffs last for as many turns as you have stacks of the debuff.
• Counter Debuffs activate when an event happens, such as playing a card.

Poison is the ONLY Debuff with both Intensity and Duration stack types.

Counter

• Orange Pellets can cleanse the player of all debuffs.
• Artifact negates the application of the next debuff received.
  • Gaining Artifact does not interact with existing debuffs on the character.

Debuffs List

Debuffs that can be found in multiple sources in the game.

Icon	Name	Source to Target	Source to Self	Description	Notes	Stacking type	Caps at
	Vulnerable	Bash, Thunderclap, Uppercut, Shockwave Terror Beam Cell Crush Joints, Indignation Trip, Bag of Marbles, Hand Drill, Fear Potion Chosen, Gremlin Nob, Red Slaver, Snecko, Writhing Mass, The Champ, The Collector, Corrupt Heart, The Guardian, Time Eater	Berserk	Receive 50% ( 25%) ( 75%) more damage from Attacks for X turns.	Applied after Strength and Vigor, then final damage rounds down. Effect can be reduced to +25% extra damage with Odd Mushroom.	Duration	Integer limit
	Weak	Clothesline, Intimidate, Shockwave, Uppercut Crippling Cloud, Heel Hook, Leg Sweep, Malaise, Neutralize, Sucker Punch Go for the Eyes Sash Whip, Wave of the Hand Blind, Red Mask, Champion Belt, Weak Potion Acid Slime (L), Acid Slime (M), Acid Slime (S), Blue Slaver, Chosen, Fat Gremlin, Giant Head, Green Louse, The Maw, Reptomancer, Romeo, Snake Plant, Snecko, Writhing Mass, The Champ, The Collector, Corrupt Heart, The Guardian, Time Eater	Doubt, Gremlin Visage	Attacks deal 25% ( 40%) less damage for X turns.	Applied after Strength and Vigor, then final damage rounds down. Specifically negated by Ginger.	Duration	Integer limit
	Frail	Fat Gremlin, The Maw, Mystic, Shelled Parasite, Snake Plant, Spheric Guardian, Spike Slime (L), Spike Slime (M)	Shame	Gain 25% less Block from cards for X turns.	Applied after Dexterity, then final Block rounds down. Specifically negated by Turnip. Shares its affected cards with Dexterity, rules can be view at Dexterity#Interactions	Duration	Integer limit
	Poison	Deadly Poison, Poisoned Stab, Bouncing Flask, Crippling Cloud, Corpse Explosion, Noxious Fumes, Envenom, Catalyst Snecko Skull, The Specimen, Twisted Funnel, Poison Potion		At the start of its turn, lose X HP, then reduce Poison by 1.	Catalyst counts as a single application for Snecko Skull and Artifact interactions. (only 9999 Poison can be applied as a single instance. This is only relevant to Specimen and having more than 9999 stacks of Noxious Fumes in the base game. This is NOT relevant to Catalyst.)	Intensity and Duration	Integer limit
	Strength Down		Flex Mutagenic Strength, Flex Potion	At the end of this turn, lose X Strength.	Internally called Flex.	Intensity	Integer limit
	Strength (Negative)	Disarm Piercing Wail, Malaise Dark Shackles Lagavulin, Spire Shield	Shifting	Decreases attack damage by X.	All negative Strength can be cleansed with Orange Pellets, resetting it to 0. Artifact can negate 1 instance of negative Strength. No ordering of Orange Pellets and healing can negate the -3 Strength inflicted by going above half hp for Red Skull, however Artifact can.	Intensity	-999 to -1
	Shackled	Piercing Wail Dark Shackles	Shifting	At the end of its turn, gains X Strength.	Buff coded as a debuff. As a result, using Piercing Wail or Dark Shackles on the turn the Corrupt Heart cleanses negative Strength will cause it to gain X Strength. And using them on the turn Time Eater, Awakened One and The Champ removes debuffs, makes the strength loss permanent. Playing Piercing Wail or Dark Shackles on an Enemy with Artifact will cause it to only lose 1 Artifact, despite being 2 Debuffs.	Intensity	0 to 999
	Dexterity Down		Speed Potion, Duality	At the end of your turn, lose X Dexterity.		Intensity	Integer limit
	Dexterity (Negative)	Lagavulin	Wraith Form	Decreases Block gained from cards by X.	Negative Dexterity can be cleansed by Orange Pellets, resetting it to 0. Artifact can negate 1 instance of negative Dexterity	Intensity	-999 to -1
	Focus (Negative)	Spire Shield	Bias, Reprogram, Hyperbeam	Decreases effectiveness of Orbs by X.	Negative Focus can be cleansed with Orange Pellets, resetting it to 0. Artifact can negate 1 instance of negative Focus. Spire Shield only has a chance of applying if Player has an Orb Slot.	Intensity	-999 to -1
	Confusion	Snecko	Snecko Eye	Whenever you draw a card, randomize its cost.	Only drawing into the card changes its cost (0–3). Fetching it with effects like Seek keeps its current cost. Confusion from Snecko Eye is applied at the start of combat and cannot negated by any Artifact, including from Clockwork Souvenir.	Doesn't stack	1
	Choked	Choke		Whenever you play a card this turn, the targeted enemy loses X HP.		Intensity	Integer limit
	Corpse Explosion	Corpse Explosion		On death, the enemy deals X times its Max HP worth of damage to ALL other enemies.		Intensity	Integer limit
	No Draw		Battle Trance Bullet Time	You cannot draw cards this turn.		Doesn't stack	1
	Wraith Form		Wraith Form	Lose X Dexterity at the start of your turn.		Intensity	Integer limit
	Bias		Biased Cognition	At the start of your turn, lose X Focus.		Intensity	Integer limit
	Lock-On	Bullseye		Lightning and Dark Orbs deal 50% more damage to this enemy.		Duration	Integer limit
	Block Return	Talk to the Hand		Whenever you attack this enemy, gain X Block.		Intensity	Integer limit
	Fasting		Fasting	Gain X less Energy at the start of each turn.		Intensity	Integer limit
	Mark	Pressure Points		Whenever you play Pressure Points, all enemies with Mark lose X HP.		Intensity	Integer limit
	No Block		Panic Button	You cannot gain Block from cards for the next X turns.		Duration	Integer limit
	Constricted	Spire Growth		At the end of your turn, take X damage.		Intensity	Integer limit
	Draw Reduction	Time Eater		Draw 1 less card for the next X turns.		Duration	Integer limit
	Entangled	Red Slaver		You may not play Attacks this turn.		Does not stack	1
	Hex	Chosen		Whenever you play a non-Attack card, add X Dazed to your draw pile.		Intensity	Integer limit
	Slow		Time Dilation Giant Head	Whenever you play a card, the target receives 10% more damage from Attacks this turn.	X is carried over on the continued turn after Vault is played. While it caps at the integer limit, the attack damage overflows to -1 long before Slow reaches it. This -1 damage deals no damage.	Intensity	Integer limit